Acute acetaminophen paracetamol toxicity Unveiling the molecular basis of paracetamol induced hepatotoxicity: Interaction of N acetyl p benzoquinone imine with mitochondrial succinate dehydrogenase ScienceDirect Mechanisms of Hepatocyte Detoxification Abdominal Key Why patients taking enzyme Inducers and patients with anorexia nervosa experience higher risk of paracetamol toxicity?? Acetaminophen (Paracetamol) is extensively metabolized by the liver via three main hepatic pathways: glucuronidation, sulfation, Paracetamol (Acetaminophen) hepatotoxicity and its management. Problem 2: N acetyl para benzoquinone (NAPQI) is an oxidized metabolite of acetaminophen formed in the liver. NAPQI is converted into an acetaminophen glutathione conjugate, a non toxic metabolite